文章信息
文章题目：Targeted MYC2 stabilization confers citrus Huanglongbing resistance
期刊：Science
发表时间：2025年4月11日
主要内容：中国科学院微生物研究所叶健团队在Science期刊上发表了题为“Targeted MYC2 stabilization confers citrus Huanglongbing resistance”的研究论文。该研究成功解析柑橘抗黄龙病核心分子机制，并利用人工智能（AI）技术筛选出可有效防控该病害的小肽。这项研究不仅破解了困扰国际农业界缺乏柑橘黄龙病抗性基因的科学难题，也为全球柑橘产业可持续发展提供了新的解决方案。
原文链接：https://science.org/doi/10.1126/science.adq7203
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研究背景
黄龙病是全球柑橘产业面临的毁灭性病害，因其潜伏期长、症状隐匿、传播迅速成为制约我国乃至世界柑橘产业高质量发展的重大问题。长期以来，由于病原菌无法分离培养，且自然抗性种质资源极为稀缺，导致相关研究和防控技术开发进展缓慢。
文章概述
本研究首次明确了E3泛素连接酶PUB21通过降解关键抗病蛋白MYC2，负向调控植物免疫响应的作用路径，发现了一个高度保守且可调控的遗传抗性网络。其中，鉴定的感病基因PUB21为柑橘抗黄龙病育种提供了明确的分子靶标，对柑橘抗性改良具有重要实践意义。基于这一机制发现，研究团队自主开发了靶向PUB21活性的高通量筛选平台，成功筛选出双功能肽APP3-14等具有显著抑制黄龙病菌活性的候选分子，为黄龙病的防控提供了小分子物质。该成果不仅丰富了植物免疫调控理论体系，更为我国柑橘黄龙病的绿色防控提供了理论支撑。
乐动平台(中国)生物产品支撑
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使用TransScript® One-Step gDNA Removal and cDNA Synthesis SuperMix (AT311）产品发表的部分文章：
• Zhao P Z, Yang H, Sun J Y, et al. Targeted MYC2 stabilization confers citrus Huanglongbing resistance [J]. Science, 2025.(IF 44.7)
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使用ProteinFind® Anti-His Mouse Monoclonal Antibody（HT501）产品发表的部分文章：
• Ou X M, Ma C Y, Sun D J, et al. SecY translocon chaperones protein folding during membrane protein insertion [J]. Cell, 2025.(IF 45.5)
• Zhao P Z, Yang H, Sun J Y, et al. Targeted MYC2 stabilization confers citrus Huanglongbing resistance [J]. Science, 2025.(IF 44.7)
• Lu P, Zhang G H, Li J, et al. A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens[J]. Science, 2025.(IF 44.7)
• Zhao S, Makarova K S, Zheng W, et al. Widespread photosynthesis reaction centre barrel proteins are necessary for haloarchaeal cell division[J]. Nature Microbiology, 2024.(IF 20.5)
• Chen X, Li W W, Gao J, et al. Arabidopsis PDLP7 modulated plasmodesmata function is related to BG10-dependent glucosidase activity required for callose degradation[J]. Science Bulletin, 2024.(IF 18.8)
• Feng L, Luo X, Huang L, et al. A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants[J]. Nature Communications, 2024,(IF 14.7)
• Li J, Liu X, Chang S, et al. The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat[J]. Science Advances, 2024.(IF 11.7)
• Li Y, Shen H, Zhang R, et al. Immunoglobulin M perception by FcμR[J]. Nature, 2023.(IF 50.5)
• Lan Z, Song Z, Wang Z, et al. Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas[J]. Cell, 2023.(IF 45.5)
• Ge L, Cao B, Qiao R, et al. SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants[J]. Molecular Plant, 2023.(IF 17.1)
• Zhong S, Li L, Wang Z, et al. RALF peptide signaling controls the polytubey block in Arabidopsis[J]. Science, 2022.(IF 44.7)
使用ProteinFind® Anti-GST Mouse Monoclonal Antibody（HT601）产品发表的部分文章：
• Zhao P Z, Yang H, Sun J Y, et al. Targeted MYC2 stabilization confers citrus Huanglongbing resistance [J]. Science, 2025.(IF 44.7)
• Lu P, Zhang G H, Li J, et al. A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens[J]. Science, 2025.(IF 44.7)
• Feng L, Luo X, Huang L, et al. A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants[J]. Nature Communications, 2024,.(IF 14.7)
• Li J, Liu X, Chang S, et al. The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat[J]. Science Advances, 2024.(IF 11.7)
• Fu X, Zhang J, Sun K, et al. Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity[J]. Cellular and Molecular Life Sciences, 2024.(IF 6.2)
• Zhou B, Luo Q, Shen Y, et al. Coordinated regulation of vegetative phase change by brassinosteroids and the age pathway in Arabidopsis[J]. Nature Communications, 2023.(IF 14.7)
• Gu P, Tao W, Tao J, et al. The D14‐SDEL1‐SPX4 cascade integrates the strigolactone and phosphate signalling networks in rice[J]. New Phytologist, 2023.(IF 8.3)
• Li N, Duan Y, Ye Q, et al. The Arabidopsis eIF4E1 regulates NRT1. 1‐mediated nitrate signaling at both translational and transcriptional levels[J]. New Phytologist, 2023. (IF 8.3)
• Liu Y, Yu T F, Li Y T, et al. Mitogen‐activated protein kinase TaMPK3 suppresses ABA response by destabilising TaPYL4 receptor in wheat[J]. New Phytologist, 2022.(IF 8.3)
